Origins and arrival in Constantinople
The tradition consistently places Domnica's origin in Carthage in Africa and her embrace of Christianity in her youth, during the reign of Theodosius the Great. She is said to have left her homeland and sailed for Alexandria before continuing on to Constantinople, where Patriarch Nektarios baptized her and she entered upon the monastic life.
A fuller version of the account relates that Domnica travelled in the company of four other young women—named in that source as Dorothea, Evanthia, Nonna and Timothea—who were baptized together with her by Nektarios. The same source adds that a monastery was established for her with imperial support, with a chapel dedicated to the Prophet Zechariah, and that she was appointed its abbess; these particulars are not given in the briefer synaxarion notice.